O-Hydroxycarboxylic acid amides

N-Sulfonyl-o-hydroxycarboxylic acid amides from sulfonic acid amides and diaryl carbonates... 

Potassium hydroxide (s. a, under H2N NH2) o-Hydroxycarboxylic acid amides from l,3-benzoxazine-2,4-diones s. 28, 898... 

The bienzymatic approach described above could also be advantageously applied to the synthesis of (R)-2-hydroxycarboxylic acids in cases where no satisfactorily enantioselective nitrilase is available (Figure 16.5). The best enantioselectivity in the hydrolysis of lb, for example, was 92% ee. The enantioselectivity of the hydroxynitrile lyase from ahnonds (PaHnL) in the synthesis of lb is also less then perfect [13], but we found that a combiCLEA of PaHnL and NIT-106 quantitatively converted 2b (O.IM starting concentration) into 3b with ee>99% R (reaction in 90 10 DlPE-buffer pH 5.5, as before) with very little (>3%) amide formation. 

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