O-Dimethoxybenzene

Figure 15 Inclusion compounds of 1,2-dimethoxyethane (a) and o-dimethoxybenzene (b) by 2. Layer structure and packing (CPK model) of these inclusion compounds. For clarity, phenyl groups of 2 and guest are unshaded and gray, respectively.

An extension of this work has resulted in the synthesis of related 6,6-disubsti-tuted (bipyridyl) ligand derivatives containing pyromellitimide spacers connected with propynyl, butynyl and propynyloxy linkers.The first of these ligands was shown to yield a chiral di-zinc(II) cationic complex of type [Zn2L2] . This species is stabilised by the presence of an aromatic guest p- or o-dimethoxybenzene) in its cavity. Related dinuclear species were also shown to form with cadmium(II) and nickel(II). 

Samples of known amounts of drugs were dissolved in CDCI3 containing the various CSAs as well as a known amount of internal standard (o-dimethoxybenzene) and H NMR spectra recorded on a 400-MHz instrument. It was checked whether the CSAs produced well-resolved peaks for both compounds, whether the CSAs were stable and had no resonances close to the signals of interest in ketoprofen, and whether the signals of the enantiomers of ketoprofen were well separated at reasonably low concentrations of the CSAs. With the exception of the naphthylethylamine, all CSAs produced good separations of optical isomer resonances, and so can be used to determine the isomeric ratio upon dissolution and metabolism. 

Interestingly, addition of BF3 etherate to the ozonolysis of o-dimethoxybenzene derivatives results in increased yields of (Z,Z)-dienes (eq 27, compare to eq 20).In this case, it is thought that coordination of the Lewis acid to the diene reduces its electron density and suppresses further attack by ozone. Also, the fact that the BF3 is already coordinated to ether may limit its ability to coordinate to ozone and increase its electrophilic reactivity. 

Pyrocatechol, 4-t-butyl-. See t-Butylcatechol Pyrocatechol dimethyl ether. See o-Dimethoxybenzene... 

Veratrol Veratrole. See o-Dimethoxybenzene Veratrole methyl ether. See Methyl eugenol Veratryl aldehyde. See Veratraldehyde Verbascum thapsis extract Verbascum thapsus. See Mullein (Verbascum thapsus) extract... 

Dihydro-a-methyl a-ionone Dihydromyrcene Dihydromyrcenyl acetate Dihydroterpineol Dihydroterpinyl acetate Diisopropyl benzaldehyde m-Dimethoxybenzene o-Dimethoxybenzene ... 

Another simple and convincing experiment is the conversion (trimerization) of o-dimethoxybenzene (III) to the analogous triphenylene ether (IV) [41]. 

In the case of 1,2-disubstituted benzenes, it was shown that anodic polymerization occurred quite differently, with o-dimethoxybenzene giving a symmetrical triphenylene (69) insoluble in most usual solvents... 

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