O-Anisic Aldehyde

Manufacturing process Manufactured from pure o-cresol (99% purity) in a similar way as p-cresol to -anisic aldehyde. The following are the steps  

Eepeated experiments in the experimental base of Atul established the process beyond doubt. Yield is 75-80% somewhat less than p-anisic aldehyde. Other catalyst systems Co-acetate/ Mn-acetate, Cu and Nickel salts have also been tried. 

Another important industrial process for manufacture of o-anisic aldehyde is based on methylation of o-hydroxy benzaldehyde or salicylaldehyde based on phenol. 

Selection of an appropriate technology for manufacture of o-anisic aldehyde would depend on whether the manufacturer is a phenol major or cresols major. 

Uses O-anisic aldehyde is a low volume fine chemical used as an intemediate in pharmaceuticals, dyes, flavor, and fragrances, etc. Uses are limited and the global demand would not exceed 500 tpa. Global key players are BASF, IFF, Givaudan, H R, etc. 

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Manufacturing process Several methods exist for reduction of o-anisic aldehyde to o-anisic alcohol, however, direct reduction by hydrogen using Raney-Nickel catalyst system at 90-100° C and 5-7 atm pressure has been commercially most attractive. Most of the key players of p-anisic alcohol such as BASF, Givaudan, Koffoeks, etc. also produce some quantities of o-anisyl alcohol. Application areas include flavor and fragrance, pharmaceuticals, etc. Global demand has been estimated at 300-350 tpa. 

Anisic alcohol. See p-Anisyl alcohol Anisic aldehyde. See p-Anisaldehyde o-Anisic aldehyde. Seeo-Methoxybenzaldehyde p-Anisic aldehyde. See p-Anisaldehyde Anisic ketone. See 1-(p-Methoxyphenyl)-2-propanone... 

Synonyms 2-Anisaldehyde o-Anisaldehyde o-Anisic aldehyde Benzaldehyde, 2-methoxy- 2-Methoxybenzaldehyde... 

Para-anisic aldehyde and p-anisic alcohol are two important p-cresol derivatives which have provided critical feedstocks for some of the important bulk drugs. Trimethoprim made from 3,4,5-trimethoxybenzaldehyde is another example. p-Cresol has already replaced gallic acid as the preferred starting material for 3,4,5-trimethoxy benzaldehyde. As more R D work is undertaken, there will no doubt emerge more finished pharmaceutical items not only from p-cresol but also from o-cresol and m-cresol. Growth of meZo-cresol has indeed been remarkable after the process was commercialized for... 

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