O-Alkylative and Silylative Passerini Three-Component Reactions

2 O-ALKYLATIVE AND SILYLATIVE PASSERINI THREE-COMPONENT REACTIONS 

An interesting variation of the Passerini 3CR is the 0-arylative Passerini reaction, where in such a process instead of the key carboxylic acid, an alkyl or aryl alcohol is employed 

Multicomponent Reactions Concepts and Applications for Design and Synthesis, First Edition. Edited by Raquel P. Herrera and Eugenia Marqu6s-L6pez. 2015 John Wiley Sons, Inc. Published 2015 by John Wiley Sons, Inc. 

The pioneering example of this new protocol was also disclosed by El Kaim, Grimaud, and coworkers using phenol derivatives 14 as carboxylic acid surrogates in a three-component addition for rendering a-aryloxy amides 15 with 

SCHEME 8.1 The classical Passerini three-component reaction. 

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