Nucleotides s. a. Oligonucleotides

Figure 1. Catalysis and template action of RNA and proteins. Catalytic action of one RNA molecule on another one is shown in the simplest case, the "hammerhead ribozyme." The substrate is a tridecanucleotide forming two double-helical stacks together with the ribozyme (n = 34) in the confolded complex. Tertiary interactions determine the detailed structure of the hammerhead ribozyme complex and are important for the enzymatic reaction cleaving one of the two linkages between the two stacks. Substrate specificity of ribozyme catalysis is caused by secondary structure in the cofolded complex between substrate and catalyst. Autocatalytic replication of oligonucleotide and nucleic acid is based on G = C and A = U complementarity in the hydrogen bonded complexes of nucleotides forming a Watson-Crick type double helix. Gunter von Kiedrowski s experi-...

A linker containing a 2,4-bis(4-carboxyphenoxy)-6-methoxy-S-triazine amide group was introduced into a oligonucleotide using reagent 207. However, an aliphatic non-nucleotide linker was found to be more effective than an aromatic linker derived from 207, in stabilising oligonucleotides triplexes. ... 

Kumar, A., and Malhotra, S. (1992) A simple method for introducing —SH group at 5 OH terminus of oligonucleotides. Nucleosides Nucleotides 11, 1003-1007. 

S. Marzabal, S. Terrazzino, B. Kuhnast, F. Dolle, J.R. Deverre, A. Jobert, C. Crouzel, L. DIGIamberardino, B. Tavitian, In vivo imaging and pharmacokinetics of oligonucleotides, Nucleosides Nucleotides 18 (1999) 1731-1733. 

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