Nucleotide recognition

Bruskov, V. I., and Poltev, V. I. (1979). On molecular mechanisms of nucleic acid synthesis. Fidelity aspects 2. Contribution of protein-nucleotide recognition. J. Theor. Biol. 78, 29-41. 

Specific nucleotide recognition in the ternary complex between the enzyme lactate dehydrogenase and the modified coenzyme NAD+-pyruvate (NAD = nicotinamide-adenine-dinucleotide). NAD+ consists of two nucleotides, adenosine-5 -phosphate and nicotinamide ribose-5 -phosphate, which are linked through a pyrophosphate bond. 

Restriaion enzymes are a revolutionary class of proteins discovered in prokaryotic organisms in the early 1970s (1-5). These enzymes reproducibly cut within double-stranded DNA molecules at specific nucleotide recognition sequences, termed restriction sites, hence their more specific appellation as restriction endonucleases (Fig. 1). Their complete range of enzymatic functions is not fully... 

Fig. 16.15. Zinc fingers of the estrogen receptor. In each of the two zinc fingers, one zinc ion is coordinated with four cysteine residues, shown in blue. The region labeled a-helix with NRS forms an a-helix that contains a nucleotide recognition signal (NRS). This signal consists of a sequence of amino acid residues that bind to a specific base sequence in the major groove of DNA. Regions enclosed in boxed arrows participate in rigid helices.

Hamilton, A. D., A. Muehldoif, S. Chang, N. Pant, S. Goswami, and D. Van Engen - Nucleotide recognition by macrocyclic receptors 27... 

Although this chapter is mainly devoted to polyamine receptors, there are other classes of receptors that are very relevant in nucleotide recognition. A few examples are discussed in this section. 

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