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Nucleosome remodeling during transcription

The basic structural unit of chromatin is the nucleosome, in which 146 bp of DNA are wrapped 1.65 turns around the histone octamer (H2A, H2B, H3, H4)2. The co-crystal structure, a histone-octamer-DNA complex, shows that the DNA wraps tightly around a cylinder-like core of the histones. The DNA is arranged such that interactions between the N-terminal tails ofhistones and adjacent nucleosomes are possible. Furthermore, the DNA wrapping around the histone core is irregular, providing some flexibility in the structure, which may be relevant for remodeling of the nucleosome during transcription. [Pg.55]

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