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Nucleosomal DNA

The primary Junction of the nucleosomes is to condense DNA. Further condensation of nucleosome DNA requires nonhistone nuclear proteins. These proteins make up a scaffoldlike structure around an additional helix consisting of coiled nucleosomes. This produces a structure that resembles a solenoid, with six nucleosome subunits per turn. The solenoid structure can form large loops that give additional structure to the incipient chromosome. [Pg.219]

Li G, Levitus M, Bustamante C, Widom J (2005) Rapid spontaneous accessibility of nucleosomal DNA. Nat Struct Mol Biol 12 46-53... [Pg.42]

Arents G, Moudrianakis EN (1993) Topography of the histone octamer surface repeating structural motifs utilized in the docking of nucleosomal DNA. Proc Natl Acad Sci U S A 90 10489-10493... [Pg.84]

Antibiotic Mg complex induced alteration in the ultrastructural changes in the native and HI depleted chromatin were monitored by thermal melting analysis, polyacrylamide gel mobility assay, dynamic light scattering experiments and transmission electron microscopic studies. Micrococcal nuclease digestion is the biochemical probe to assess the accessibility of the antibiotic Mg + complexes to nucleosomal DNA. [Pg.157]

The antibiotic complexes bind to nucleosomal DNA in presence of histones... [Pg.158]

Kurten S, Obe, G (1975) Premature chromosome condensation in the bone marrow of Chinese hamster after pUcation of bleomycin in vivo. Mutat Res 27(2) 285—294 Lee DY, Hayes JJ, Pruss D, Wolffe AP (1993) A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell 72 73—84... [Pg.185]

I. loshikhes, A. Bolshoy, K. Derenshteyn, M. Borodovsky, and E. N. Trifonov, Nucleosome DNA sequence pattern revealed by multiple alignment of experimentally mapped sequences. J. Mol. Biol. 262, 129-139 (1996). [Pg.245]

Nucleosomes isolated and purified from chicken erythrocytes and beef kidney crystallized and diffracted to limits of 5-6 A, but led to structural models of 7-8 A resolution [12,14], In these structures, the path of the DNA around the histone core is clearly seen. With the exception of positions about 1.5 and 4.5 helical turns from the center of the nucleosomal DNA in either direction, the DNA appears uniformly bent. Significant compression of the DNA occurs where the minor grooves face... [Pg.14]

See other pages where Nucleosomal DNA is mentioned: [Pg.142]    [Pg.143]    [Pg.212]    [Pg.213]    [Pg.213]    [Pg.27]    [Pg.29]    [Pg.31]    [Pg.9]    [Pg.12]    [Pg.36]    [Pg.36]    [Pg.38]    [Pg.52]    [Pg.72]    [Pg.78]    [Pg.78]    [Pg.79]    [Pg.103]    [Pg.117]    [Pg.124]    [Pg.148]    [Pg.148]    [Pg.157]    [Pg.159]    [Pg.160]    [Pg.168]    [Pg.169]    [Pg.177]    [Pg.178]    [Pg.182]    [Pg.186]    [Pg.270]    [Pg.206]    [Pg.238]    [Pg.142]    [Pg.18]    [Pg.45]    [Pg.60]    [Pg.62]    [Pg.65]    [Pg.67]   
See also in sourсe #XX -- [ Pg.143 ]

See also in sourсe #XX -- [ Pg.256 , Pg.257 ]



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Nucleosome

Nucleosomes

Physical properties of nucleosomes and DNA

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