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Nucleosides linkage isomers

The most convincing evidence in favor of a uniform 3,5-diester linkage between nucleotides has been obtained by the action of various enzymes on synthetic diesters of known constitution.218 217 Ribonuclease and spleen extracts were found to act only on nucleoside 3-(benzyl hydrogen phosphates), but not on other isomers, to give nucleoside cyclic phosphates which are broken down further to give nucleoside 3-phosphates. It is concluded, by analogy, that polynucleotides, which are substrates for these enzymes, also possess ester groupings at the 3-positions, rather than at the... [Pg.325]

In natural DNA the 2 hydroxyl group of libose has been removed, and the only possible linkage is from position 3 on one nucleoside to position 5 of another. For other reasons we had become interested in using an isomer in which the 3 hydroxyl of ribose was removed so the... [Pg.118]

See other pages where Nucleosides linkage isomers is mentioned: [Pg.186]    [Pg.225]    [Pg.122]    [Pg.154]    [Pg.201]    [Pg.159]    [Pg.164]    [Pg.381]    [Pg.194]    [Pg.42]    [Pg.42]    [Pg.194]    [Pg.222]    [Pg.302]    [Pg.49]    [Pg.208]    [Pg.259]    [Pg.119]    [Pg.149]   
See also in sourсe #XX -- [ Pg.186 ]

See also in sourсe #XX -- [ Pg.186 ]



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Isomer linkage

Nucleosides linkage

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