Nucleophilic aromatic substitution aryl-copper complexes

An extensive series of neutral macrocyclic complexes, mainly of nickel(II), copper(II), platinum(II) and palladium(II), has been developed by Dziomko and coworkers. The cyclization step in the template reaction is a nucleophilic aromatic substitution of an arylamine on to a haloaryl azo compound. A variety of aryl and heteroaryl rings can be incorporated in different combinations. For instance, a diaminoazo compound can be combined with a dihaloazo compound (Scheme 58).246 247 Another synthetic strategy involves the dimerization of an aminohaloazo compound and leads to more symmetrical macrocyclic complexes (Scheme 59).248 249 Most recently, dihalodiazo compounds have been synthesized from dihydrazines and pyrazolinediones and undergo template reactions with simple 1,2-diamines (Scheme 60).249 250... 

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