Nucleophilic addition to carbonyl groups aldehydes and ketones

1 Nucleophilic addition to carbonyl groups aldehydes and ketones [Pg.221]

However, since the contribution from B is smaller than that from A, the charge distribution is often presented as in C. The partial charges 8+ and 8— indicate the imbalance in electron density. [Pg.221]

Because of the polarization, it is possible for the carbonyl group to be involved in both nucleophilic addition reactions and electrophilic addition reactions. [Pg.221]

Essentials of Organic Chemistry Paul M Dewick 2006 John Wiley Sons, Ltd [Pg.221]

Most addition reactions actually involve both steps, but the order in which these occur depends on the nature of the reagent and the reaction conditions. Under basic conditions, the nucleophile attacks [Pg.222]

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