Nucleophilic Addition-Cyclization of a-Haloesters

Reactions of Carbon Nucleophiles with Carbonyl Compounds 

Trimethylsilylepoxides can be prepared by an addition-cyclization process. Reaction of chloromethyltrimethylsilane with sec-butyllithium at very low temperature gives an a-chloro lithium reagent that leads to an epoxide on reaction with an aldehyde or ketone.291 

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