Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Nucleic acids possible errors

Mass mapping is not without possible errors in accuracy. Mass loss accounts for inaccuracies, especially in proteins. Wall and Hainfield (17) report that a dose of 10e /0.1nm2 is a reasonable compromise between structural preservation and accuracy of mass measurements. Use of a cold specimen stage is requisite. Since proteins, nucleic acids, and lipids suffer mass loss at different rates, a dose-... [Pg.80]

In contrast to Mg + and Mn +, which stabilize secondary structures in DNA and RNA, Cu + destabilizes DNA and RNA double helices, and this is attributed to the ability of copper to bind to the nucleic acid bases. Chao and Kearns have recently explored the possibility that this binding, as detected by electron and nuclear magnetic resonance spectroscopy, might be used to probe certain structural features of nucleic acid molecules, such as the looped out regions of tRNAs. The nature of the Cu complexes formed with nucleosides and nucleotides varies with the specific nucleic acid derivatives used and also the pH. Thus, in the pH range 8.5—10.0, copper forms a water-soluble complex with the ribose OH groups of the ribonu-cleosides and 5 -ribonucleotides, but these complexes cannot form with any of the deoxynucleosides or the 2 - and 3 -ribonucleotides. It is suggested that copper(ii) could stabilize unusual polynucleotide structures or interactions in certain enzymatic systems the latter could, for example, be responsible for translational errors in the RNA,DNA polymerase system which are known to be induced by transition metals. [Pg.305]

Less than two years have elapsed since the first English edition was published. Evidently the volume has been favorably accepted. The second edition gives a welcome opportunity to eliminate some errors and to include in the English version the revisions made in the fourth German edition (1964). The chapter on nucleic acids has been largely reorganized in addition, newer developments have been included wherever possible. It is hoped that this new edition will fulfill its purpose to provide an understanding of the chemical phenomena of life. [Pg.443]


See other pages where Nucleic acids possible errors is mentioned: [Pg.321]    [Pg.233]    [Pg.440]    [Pg.180]    [Pg.12]    [Pg.80]    [Pg.253]    [Pg.270]    [Pg.45]    [Pg.307]    [Pg.79]    [Pg.413]    [Pg.82]    [Pg.31]    [Pg.127]    [Pg.351]    [Pg.304]    [Pg.295]    [Pg.2472]    [Pg.1221]    [Pg.126]    [Pg.234]    [Pg.154]   
See also in sourсe #XX -- [ Pg.316 ]




SEARCH



Acid error

© 2024 chempedia.info