Nucleic acids molecular recognition

These examples show that for difficult cases, and especially when a prediction is being made, a large number of simulations may be necessary. Today, the continuing increase in computer power has made such multiple simulations possible in a reasonable time frame. Several other recent studies illustrate the scope of molecular dynamics free energy for molecular recognition problems they include studies of nucleic acids [13], proteins [14-16], and methodological studies of convergence and precision [17, 18]. Several recent reviews provide additional examples [19, 20]. 

Cech TR, Herschlag D (1996) Group I ribozyme substrate recognition, catalytic strategies and comparative mechanistic analysis. In Eckstein F, Lilley DMJ (eds) Nucleic acids and molecular biology, vol 10, catalytic RNA. Springer, Berlin Heidelberg New York, P 1... 

Nucleic acids, proteins, some carbohydrates, and hormones are informational molecules. They carry directions for the control of biological processes. With the exception of hormones, these are macromolecules. In all these interactions, secondary forces such as hydrogen bonding and van der Waals forces, ionic bonds, and hydrophobic or hydrophilic characteristics play critical roles. Molecular recognition is the term used to describe the ability of molecules to recognize and interact bond—specifically with other molecules. This molecular recognition is based on a combination of the interactions just cited and on structure. 

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