Nucleic acids laser-Raman spectroscopy

Study of the vibrations in the low-frequency region that are associated with the D-ribosyl ring in nucleosides was achieved204 with F.t.-i.r. and Raman spectroscopy. Numerous other investigations of nucleosides, nucleotides, and nucleic acids have been conducted by use of laser-Raman spectroscopy this work has been reviewed by different authors.I36 205-207 The spectral... 

S.C. Erfurth, E. J. Kier, and W. L. Peticolas, Determination of the Backbone Structure of Nucleic Acids and Nucleic Add Ohgomers by Laser Raman Spectroscopy, Proc. Natl. Acad. Sci. USA 69, 938-941 (1972). 

In classic UV Raman systems, an excimer laser was used to pump a frequency-doubled dye laser which was then directed at the liquid sample as it was jetted along a guided path. Recently, UV Raman spectroscopy has become more feasible due to the advent of a frequency-doubled Ar+ laser that has five excitation wavelengths with substantial power in the UV region. This laser yields better signal-to-noise ratios and allows for UV Raman investigation of solid samples. The most recent UV Raman studies examine protein-nucleic acid interactions, protein-protein interactions, and the stmcture and behavior of proteins, DNA, and neurotransmitters in aqueous solutions. 

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