Nucleic acids human genome sequencing

Wolfsberg, T. G., and Landsman, D. (1997). A comparison of expressed sequence tags (ESTs) to human genomic sequences. Nucleic Acids Res 25 1626-1632. 

After completion of the human genome sequences in the year 2000, the challenge was immediately redirected to using these data to interpret the function of proteins. Nucleic acids and proteins are inseparable components of the process of life. Nucleic acids direct the production of proteins, but it is the proteins that carry out the body s functions. Today, research in nucleic acids is always deeply intertwined with research of proteins and vice versa. 

Human genome Nucleic acid sequences representing endogenous retroviruses are com-... 

Less than one-third of human genomic DNA consists of genes. Much of the remainder consists of repeated sequences of various types. Nucleic acid parasites known as transposons account for about half of the human genome. 

The methods of nucleic acid sequencing have now advanced to such an extent that the United States and other national governments are funding a 10-20 year project to sequence the entire human genome [10,11] at an estimated cost of 3 billion. The genome is the complete genetic blueprint of a human being. It consists of twenty four distinct chromosomes (twenty two pairs of autosomes... 

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