Nucleic acids folding

Zuker, M., Mfold web server for nucleic acid folding and hybridization prediction, Nucleic Acids Res. 2003, 31, 3406 3415... 

Because conformational changes in RNA or short DNAs typically cause small changes in electrophoretic mobility, analysis of nucleic acid folding requires careful optimization of electrophoresis conditions. By contrast, protein—nucleic acid interactions are typically easier to analyze by native PAGE because the molecular weight and positive charge of the protein produces a relatively large shift in gel mobility. 

Tempcrature-jump methods have not been used in soil science. However, they have been widely employed in many areas of chemistry and biochemistry research to study the following types of reactions (Turner, 1986) electron transfer, enzyme catalysis, metal complex formation, nucleic acid folding, proton transfer, spin equilibria, and protein-ligand binding. 

The Study of Nucleic Acid Folding and Heteroduplex Formation. . 54... 

N.R. Markham, M. Zuker, UNAFold software for nucleic acid folding and hybridization, Methods Mol. Biol. (Clifton, NJ) 453 (2008) 3-31. 

Nickel Complexes as Probes of Guanine Sites in Nucleic Acid Folding... 

Markham, N.R. and Zuker, M. UNAFold—Software for nucleic acid folding and hybridization. Methods in Molecular Biology Volume II Structure, Function and Applications 453,3-31,2008. 

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