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Nucleic acids electrochemical aptasensor development

A reusable electrochemical electrode for the use of low-molecular-weight molecules by its aptamers was demonstrated with the development of an electrochemical aptasensor for adenosine monophosphate (Wu et al., 2007). The anti-adenosine aptamer was functionalized at its end with a redox-active ferrocene unit. An electrode was functionalized with nucleic acid complementary to a region of the aptamer, and this was hybridized to the redox-tethered aptamer, giving rise to a redox response. In the presence of adenosine, an adenosine-aptamer complex was formed, resulting in dissociation of the redox-tethered aptamer from the surface and depletion of the redox signal. The extent of the decrease in electrical response was controlled by concentration of the adenosine analyte. [Pg.70]

Indirect amplified electrochemical analysis of aptamer-protein complexes has employed nanoparticles as labels for the development of electrochemical aptasensors. The use of metal nanoparticles as tracers for the analysis of nucleic acid... [Pg.73]


See other pages where Nucleic acids electrochemical aptasensor development is mentioned: [Pg.363]    [Pg.67]    [Pg.68]    [Pg.73]    [Pg.76]    [Pg.386]   


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