Nucleic acid metabolism and

Phosphatidylinositol Synthesis. The symptoms of inositol depletion include a decreased hyphal extension rate, increased branching and cell lysis. Other changes occur in protein, carbohydrate and nucleic acid metabolism, and reduced activity levels of membrane-bound wall biosynthetic enzymes.7... 

This group of herbicides has many diverse modes of action. The mode of action of most of the members of this group is by interfering with photosynthesis, or by interfering with cell division in meristematic tissues (growing termini). This later action is effected by impairing nucleic acid metabolism and protein synthesis. 

K7. Kitiyakara, A., Cytologic study of dystrophia muscularis mouse muscles. Observations on nucleic acid metabolism and nuclear distribution. Arch. Pathol. 71, 579 (1961). 

Conversion to the isopropylamine salt is carried out before it is used as a herbicide. Its mode of action appears to be interference with the biosynthesis of aromatic amino acids such as phenylalanine. This in turn inhibits nucleic acid metabolism and protein synthesis. 

There are arguments for interpreting the action of aldosterone on active sodium transport by toad bladder, colon and skin as due to a hormone-induced multiplication of the sites of penetration of sodium into the cell, across its apical border (Crabbe, 1967) this requires the intervention of nucleic acid metabolism and the effect of aldosterone is blocked by actinomycin D. This drug actually fails to interfere significantly with the reaction of toad skin to insulin before paired preparations were stimulated with insulin, short-circuit current (uk/cm S.E.) averaged 42.4 + 2.6 for the control, 36.1 1.4 for the matched fragments exposed for 2 hours to actinomycin D, 10 2 hours after addition of insulin to both... 

Inhibitors not primarily involving photosynthesis.—Of the herbicides which do not inhibit photosynthesis, the phenoxycarboxylic herbicides have received the most attention with respect to their influence on the soil algae. These herbicides act on higher plants through interfering with nucleic acid metabolism and disrupting translocation systems. 

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