Nuclear magnetic resonance solvent suppression

Bottomley PA (1987) Spatial localization in NMR spectroscopy in vivo. Ann NY Acad Sci 508 333-348 Bottomley PA, Edelstein WA, Foster TH, Adams WA (1985) In vivo solvent-suppressed localized hydrogen nuclear magnetic resonance spectroscopy a window to metabolism Proc Natl Acad Sci USA 82 2148-2152 Brown TR, Kincaid BM, Ugurbil K (1982) NMR chemical shift imaging in three dimensions. Proc Natl Acad Sci USA 79 3523-3526... 

Nuclear magnetic resonance (NMR) spectroscopy has proven to be the most versatile technique to study organometallic compounds both non-aqueous and aqueous solutions [6, 7]. To explore all the possibilities of NMR one has to either work in DzO as solvent or use a water signal suppression technique. Proton chemical shifts can give information about the structure. Generally, protons bound to carbons coordinated to a metal center show a low-field shift, about 1-4 ppm, compared with the metal-free environment. Metal hydrides usually have negative... 

Key Words Nuclear magnetic resonance spectroscopy, Solvent, Water suppression. Radiation damping. Demagnetization field. Bulk susceptibility effect. Presaturation, Watergate, Purge, Metabonomics. 

B. L. Tomlinson and H. D. W. Hill, "Fourier synthesized excitation of nuclear magnetic resonance with application to homo-nuclear decoupling and solvent line suppression," J. Chem. Phys. 59, 1775-1784 (1973). 

Nuclear magnetic resonance (NMR) (see Chapter 10) Although stopped flow and online results have been published, SEC-NMR coupling is still not a standard technique [2]. The use of deuterated solvents or the need to suppress the intense solvent signals by special NMR pulse sequences has limited the applicability. An additional problem is the low sensitivity of NMR in combination with the low concentrations used in SEC. 

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