Nuclear drug Target

Tobin, J. F., and Freeman, L. P. (2006). Nuclear receptors as drug targets in metabolic diseases New approaches to therapy. Trends Endocrinol. Metab. 17, 284-290. 

Aronsohn, A.I. and Hughes, J.A. (1998) Nuclear localization signal peptides enhance cationic liposome-mediated gene therapy. J. Drug Target., 5, 163-169. 

Reverse transcription (which occurs in both prokaryotes and eukaryotes) is the synthesis of DNA from an RNA template. A class of RNA viruses, called retroviruses, are characterized by the presence of an RNA-dependent DNA polymerase (reverse transcriptase). The vims that causes AIDS, Human Immunodeficiency Virus (HIV), is a retro-vims. Because nuclear cell division doesn t use reverse transcriptase, the most effective anti-HIV drugs target reverse transcriptase, either its synthesis or its activity. Telomerase, discussed in the previous section, is a specialized reverse transcriptase enzyme. See Figure 12-5. 

Ligand Activation of Nuclear Receptors ER The Drug Target Darling... 

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