NSAIDs Sulphonylureas

Examples of some drugs whose activity is increased in liver disease include oral anticoagulants, metformin, chloramphenicol, NSAIDs and sulphonylureas. It is well known that drugs such as opioids should be used in reduced dosage in patients with hepatic dysfunction doses need to be titrated, Therefore, if adverse drug interactions with opioids occur in patients with liver dysfunction, the consequences such as respiratory depression could be life-threatening,... 

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