Pentoxifylline NSAIDs

PENTOXIFYLLINE ANALGESICS - NSAIDS Risk of bleeding when pentoxifylline is given with ketorolac post surgery Uncertain possibly additive antiplatelet effect Avoid co-administration of pentoxifylline and ketorolac... 

A review of bleeding events associated with the use of postoperative ketorolac revealed that a small number of patients were also taking pentoxifylline. The UK manufacturers therefore recommend that this drug combination should be avoided, whereas the US manufacturers make no mention of this tentative interaction. There seems to be no evidence regarding this interaction with other NSAIDs. 

ASA, NSAIDs, COX-2 seleaive inhibitors, pentoxifylline, drotrecogin alfa, pentosan polysulfate sodium, omega-3-acid ethyl ester can have enhanced antiplatelet efferts and increased bleeding. 

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