NSAIDs Ofloxacin

Fillastre JP, Leroy A, Borsa-Lebas F, Etienne I, Gy C, Humbert G. Effects of ketoprofen (NSAID) on the pharmacokinetics of pefloxacin and ofloxacin in healthy volunteers. Drugs Exp Clin Res 1992 18(ll-12) 487-92. 

A number of cases of convulsions have been seen in Japanese patients given fenbufen with enoxacin, and there is also one possible case involving ofloxacin. Use of these particular drugs together should be avoided. Normally no interaction seems to occur with most quinolones and NSAIDs, except where there is a predisposition to convulsive episodes. Isolated cases of convulsions, other neurological toxicity or skin eruptions have been seen when ciprofloxacin was given with indometacin, mefenamic acid or naproxen. These appear to be very rare events. 

One patient taking fenbufen 800 mg had involuntary movements of the neck and upper extremities after taking ofloxacin 600 mg. The pharmacokinetics of ofloxacin 200 mg twice daily were unchanged by ketopro-fen 100 mg daily for 3 days in 10 healthy subjects. The incidence of psychotic adverse effects (euphoria, hysteria, psychosis) in 151 patients on ofloxacin were not increased by the concurrent use of NSAIDs (aspirin, diclofenac, indometacin, dipyrone)."... 

JUngst G, Weidmann E, Breitstadt A, Huppertz E. Does ofloxacin interact with NSAIDs to cause psychotic side effects 17th International Congress on Chemotherapy, Berlin, June 23-8,1991, Abstract 412,... 

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