NSAIDs mechanism of action

Herbette, L. G. Vecchiarelli, M. Tmmlitz, G., NSAID Mechanism of Action Membrane Interactions in the Role of Intracellular Pharmacokinetics, Vane, Botting, Botting, pp. 85-102 (1995). 

NSAIDs mechanism of action relays inhibition of production of prostanoids to prevent the inflammatory pain. Two cyclooxygenase enzymes contribute to the conversion of arachidonic acid to prostaglandin H2 cyclooxygenase-1 (COX-1) is a constitutive form of cyclooxygenase but COX-2 tends to be induced primarily by inflammation in most tissues. Many recent medications and investigations are directed at inhibiting COX-2 to relieve pain, such as celecoxib. 

Figure 48,2. NSAIDs mechanism of action (adapted from httpy/www.arcoxia.ae).

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