NSAIDs inflammation, signs

NSAIDs are a reasonable alternative when acetaminophen fails to provide an acceptable analgesic response. Some authorities recommend NSAIDs over acetaminophen for patients presenting with severe pain or signs and symptoms of inflammation, but this is a matter of much contention. The rationale for this recommendation is that acetaminophen s central mechanism of action renders it ineffective against peripheral joint inflammation, and therefore, less effective.18 Consensus guidelines support the use of NSAIDs as an alternative to acetaminophen if clinical features of peripheral inflammation or severe pain are detected.11,12 Unfortunately there is no validated mechanism to identify patients who are more likely to respond to NSAIDs than acetaminophen. 

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat the signs and symptoms of inflammation, particularly arthritic pain. - It is mainly through the inhibition of cyclooxygenases (COXs), key enzymes in prostaglandin (PG) biosynthesis from arachidonic acid, that NSAIDs exert their anti-inflammatory effect. 

Valdecoxib is a nonsteroidal antiinflammatory drug (NSAID) that inhibits inflammation, pain, and fever, probably by inhibition of cyclooxygenase-2 (COX-2). It is indicated in the relief of signs and symptoms of osteoarthritis and adult rheumatoid arthritis and treatment of primary dysmenorrhea. 

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