Nozaki-Hiyama-Kishi reaction diastereoselectivity

This chapter will review the literature up to the end of 2011 on the stereoselective Nozaki-Hiyama-Kishi reaction and applications in natural product synthesis. The transformation of the NHK reaction from using stoichiometric to catalytic amounts of chromium will be addressed initially then the diastereoselective NHK, followed by the enantioselective version (with an emphasis on the different classes of chiral ligands that have been employed in a wide variety of carbon-carbon bond forming processes), and finally, selected examples of the application of the NHK reaction to natural product synthesis will be described. 

G. Dutheuil, X. Lei, X. Pannecoucke, J.C. Quirion, A novel diastereoselective synthesis of (Z)-fluoroalkenes via a Nozaki-Hiyama-Kishi-Type reaction, J. Org. Chem. 70 (2005) 1911-1914. 

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