Noyori techniques

Noyori et al. (17) applied this catalyst to the asymmetric cyclopropanation of al-lenes and found that carbenoid transfer occurred selectively to the internal alkene, Eq. 4 (17). The product cyclopropanes 9 and 10 were formed in optically active form but the ee could not be determined, a reflection of the lack of analytical techniques available at the time. 

As recently recognized by the Nobel Chemistry award committee, the conceptualization, development, and commercial application of enantioselective, homogeneous hydrogenation of alkenes represents a landmark achievement in modem chemistry. Further elaboration of asymmetric hydrogenation catalysts by Noyori, Burk, and others has created a robust and technologically important set of catalytic asymmetric synthetic techniques. As frequently occurs in science, these new technologies have spawned new areas of fundamental research. Soon after the development of... 

In the light of the above set of examples, it is obvious why it is so important to produce chirally pure substances [68], Three scientists from among those who worked out reliable and efficient techniques for this purpose were awarded the Nobel Prize for Chemistry in 2001, K. Barry Sharpless, William S. Knowles, and Ryoji Noyori. The Swedish academician who introduced the three scientists at the award ceremony stressed that they have developed chiral catalysts in order to produce only one of the [chiral] forms [69], Chiral production and separation continue to be among the most practical problems in the application of chemical advances [70],... 

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