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Novel quinoxaline derivatives, synthesis

The synthesis of novel quinoxaline derivatives was key in the study of inhibitors of Pirn kinases. This structure-activity relationship (SAR) study found several promising molecules that demonstrated antiproliferative properties against solid cancer cell lines (PAl, PC3, and DU145). The synthesis of these compounds relied on the previously optimized condensation of diamines with a-halogenated carbonyls followed by oxidation to provide the aromatic bicycle. ... [Pg.542]

Many more results were reported in the area of the isomeric [l,2,4]triazolo[4,3-tf]quinoxaline derivatives. With one exception, however, all these studies applied known recognized ring-closure techniques for the synthesis of novel derivatives, in many cases of biological importance (cf. Section 11.16.8.) In Table 15, these derivatives are summarized together with the literature references. [Pg.730]

Ghorbani VR, Flajinazari S (2013) Poly-(Af, Af-dibromo-Af-ethyl-benzene-l,3-disulphon-amide) and A(jV, A-tetrabromobenzene-l,3-disulphonamide as novel eatalysts for synthesis of quinoxaline derivatives. J Chem Sci 125 353-358... [Pg.62]

Khaksar S, Rostamnezhad F (2012) A novel one pot synthesis of quinoxaline derivatives in fluorinated alcohols. Bull Korean Chem Soc 33 2581-2585... [Pg.65]

Sahu R, Tiwari S, Chandra JK, Patel PK (2012) Synthesis and anticonvulsant activity of some novel semicatbazone derivatives containing quinoxaline moiety. Int J Pharm Sci Res 3 (ll) 4549-4553... [Pg.127]

Azizian, J., Karhni, A.R., Kazemizadeh, Z., Mohammadi, A.A., Mohammadizadeh, M.R. 2005. Silica snlfuric acid-catalyzed reaction of 4-hydroxy proUne with llH-indeno[l,2-b] quinoxalin-ll-one and isatin derivatives A novel synthesis of new pyrrole compounds. Synthesis 1095-1097. [Pg.36]

Piancatelli G, Scettri A, D Auria M (1977) The oxidation of furan derivatives with pyridinium chlorochromate a novel synthesis of 6-hydroxy-27f-pyran-3(67f)-ones. Tetrahedron Lett 18 (25) 2199-2200. doi 10.1016/S0040-4039(01)83720-5 Pleshakov VG, Abedin MZ, Sergeeeva ND, Prostakov NS (1983) Formation of 9-methylisoindolo [l,2-c]quinoxaline by catalytic dehydrocyclization of 2-(2,4-dimethylphenyl)quinoxaline. J Org Chem, USSR (Engl Transl) 19(3) 586-587... [Pg.207]

Also new is the synthesis of benzo[g]pteridines (293) outlined in Scheme 69. Formation of the key intermediate quinoxaline (292) involves a novel aromatiza-tion of the chlorotetrahydro-derivative (291), a tentative mechanism for which is illustrated. [Pg.202]


See other pages where Novel quinoxaline derivatives, synthesis is mentioned: [Pg.59]    [Pg.126]    [Pg.214]    [Pg.59]    [Pg.106]    [Pg.108]    [Pg.110]    [Pg.111]    [Pg.118]    [Pg.126]    [Pg.129]    [Pg.129]    [Pg.130]    [Pg.132]    [Pg.266]    [Pg.269]    [Pg.444]    [Pg.171]    [Pg.143]    [Pg.182]    [Pg.222]    [Pg.205]    [Pg.110]    [Pg.352]    [Pg.306]    [Pg.112]    [Pg.122]    [Pg.128]    [Pg.410]    [Pg.419]    [Pg.420]   
See also in sourсe #XX -- [ Pg.542 ]




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