Norwich Eaton

A solution of l-amino-3-[4-(4-methyl-l-piperazinyl)butyl]-2,4-imidazolidinedione hydrochloride (0.0094 mole), dimethylformamide (75 ml) and 5-(4-chlorophenyl)-2-furancarboxaldehyde [prepared as described in U.S. Patent No. 20 4,882,354, to Huang et al., assigned to Norwich Eaton Pharmaceuticals, Inc., issued November 21, 1984 see Cols. 7 and 8] (1.94 g, 0.0094 mole) is stirred at room temperature for 72 h. The mixture is filtered, collecting the solid. Recrystallization from absolute ethanol/H20 and air-drying gives 2.63 g (0.0050 mole) of l-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]3-[4-(4-methyl-l-piperazinyl)butyl]-2,4-imidazolidinedion hydrochloride. 

Norwich Eaton Norwich Eaton Oberval Croce Bianca Arnaldi S.A.M. 

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