Nontuberculosis mycobacteria

S pneumoniae, S aureus, H influenzae, Moraxella catarrhaiis, mycoplasmas, Legionella, Chlamydia, H pylori, N gonorrhoeae, fragilis, T gondii, and nontuberculosis mycobacteria. Many macrolide-resistant strains are susceptible to ketolides because the structural modification of these compounds renders them poor substrates for efflux pump-mediated resistance and they bind to ribosomes of some bacterial species with higher affinity than macrolides. 

The mechanism of action and other pharmacologic features of streptomycin are discussed in Chapter 45. The typical adult dose is 1 g/d (15 mg/kg/d). If the creatinine clearance is less than 30 mL/min or the patient is on hemodialysis, the dose is 15 mg/kg two or three times per week. Most tubercle bacilli are inhibited by streptomycin, 1-10 mcg/mL, in vitro. Nontuberculosis species of mycobacteria other than Mycobacterium avium complex (MAC) and Mycobacterium kansasii are... 

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