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Nonlinear effect chiral reagents

The topic of chiral amplification has been reviewed, but is most well understood in the alkylation of aldehydes with dialkylzinc reagents. The origin of the remarkable positive nonlinear effect is due to dimerisation of alkylzinc intermediates. In order for reaction to occur, the aldehyde must be able to coordinate to the zinc atom of the monomer (6.19). However, the monomer (6.19) is in equilibrium with the dimer (6.18). When the dimer is comprised of the two different enantiomers of aminoalcohol (heterochiral) it is particularly stable and reaction does not proceed through it. However, the dimer comprised of aminoalcohols of the... [Pg.150]

See other pages where Nonlinear effect chiral reagents is mentioned: [Pg.164]    [Pg.105]    [Pg.158]    [Pg.216]    [Pg.289]    [Pg.601]    [Pg.38]    [Pg.145]    [Pg.131]   
See also in sourсe #XX -- [ Pg.289 , Pg.290 ]



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