Nondepolarizing neuromuscular poison

Methyllycaconitine (38) occurs in numerous Delphinium species. The hydroiodide of this alkaloid shows curare-like properties greater than those of aconitine (27) or mesaconitine (34). This compound is a potent, nondepolarizing neuromuscular poison, acting as a competitive inhibitor of acetylcholine at nicotinic receptors in the same way as tubocurarine (Benn and Jacyno, 1983). Methyllycaconitine (38) has an LD50 i.v. in mouse of 5-18 mg/kg (Wink, 1993). 

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