Noncovalent DNMT Inhibitors

These inhibitors act directly on the enzyme without the necessity for incorporation into the DNA. In theory, this should shift the dual activity of reactivation of silenced genes and cytotoxicity towards the epigenetic effects which may result in reduced side-effects. But the proof for that remains yet to be established. 

There are also some natural products that were identified as inhibitors of DNMTs [87]. Certain disulfide bromotyrosine derivatives, such as psammaplin 

A further natural product inhibitor is mithramydn A, a structurally complex anticancer antibiotic. Mithramycin A is a member of a group of aureolic add-type polyketides that are produced by the soil bacterium Streptomyces argillaceus [94]. 

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