Noncorrin Co-containing Enzymes

Pita bread is a round pocket bread, widely consumed in Middle Eastern, Mediterranean, and Balkan cuisines. The pocket is created by steam, which puffs up the dough as the bread cools and flattens, it leaves a pocket in the middle. 

FIGURE 15.13 Type 1 and type 2 MetAPs ( pita-bread enzymes), (a) E. coli MetAP-1 (b) P. furiosis MetAP-2 (c) human MetAP-2. In contrast to the type 1 enzymes, type 2 MetAPs contain an a-helical subdomain (orange) inserted within the catalytic domain (cyan and green a-helices and p-strands, respectively). (From Lowther Matthews, 2002. Reprinted with permission of the American Chemical Society.) 

FIGURE 15.14 Comparison of the dinuclear metal centres and flanking His residues of E. coli MetAP-1 (red) and its relatives. (From Lowther Matthews, 2002. Reprinted with permission of the American Chemical Society.) 

Banerjee, R., Ragsdale, S. W. (2003). The many faces of vitamin B12 catalysis by cobalamin-dependent enzymes. The Annual Review of Biochemistry, 72, 209—247. 

Banerjee, R., Gherasim, C., Padovani, D. (2009). The tinker, tailor, soldier in intracellular B12 trafficking. Current Opinion in Chemical Biology, 13, 484—491. 

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