Non receptor triggers reactive oxygen species and nitric oxide

Non receptor triggers reactive oxygen species and nitric oxide 

Mitochondria are the site of ROS production during ischemia. Arachidonic acid, eNOS, NADPH oxidase and xanthine oxidase are sources of reactive oxygen species at reperfusion. Cytochrome P450 monooxygenases (CYPs) have also been implicated. CYP catalyzes arachidonic acid oxidation to a variety of biologically active eicosanoids and generates reactive oxygen species.1 3 

Paradoxically, ROS are not only injurious but may also be protective. ROS are shown to upregulate survival signaling.119 Furthermore, the cardioprotective abilities of ischemic preconditioning are completely abolished with the administration of N-acetylcysteine indicating that ROS can act as important mediators of the preconditioning response.120 (See also chapter 3). 

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