Non-covalent organocatalysi

Select applications of chiral Brpnsted acid, chiral Brpnsted base, and chiral PTC have been demonstrated in this chapter as representative examples of asymmetric non-covalent organocatalytic processes. To farther directly contrast covalent and non-covalent organocatalysis, two case studies that highlight select acyl transfer and pericyclic strategies follow. 

Halogcm Braiding in Organic Synthesis and Non-covalent Organocatalysis. 170... 

In contrast to conventional reaction setups, multicomponent approaches require a significantly higher level of chemoselectivity. Therefore, applications of enantioselective non-covalent organocatalysis in reactions of three and more components still remain limited in number. The potential of catalysts with a non-covalent mode of action to overcome the inherent difficulties of multicomponent reactions to be performed stereoselectively, however, makes these transformations particularly worthy of investigation. This section focuses on recent successes in this direction. 

Scheme 42.24 Overview of multicomponent reactions rendered enantioselective by non-covalent organocatalysis. Conceptually, these approaches rely either on (i) protonation of an imine species formed in...

Alternatively, organocatalysis can moderate reactivity and generate enantioselectivity through non-covalent interactions for the purpose of this review, reactions promoted through this pathway can be considered... 

Review of non-covalently-supported organocatalysis Zhang, L, Luo, S., and Cheng, J.-P. (2011) Catal. Sci. Technol.,... 

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