Non-coding strand

Antisense is by no means an artificial concept. Apart from basic coding/non-coding strand interactions, a series of cases has been found in nature, in which gene regulation is effected by antisense-type nucleic acid/nucleic acid interactions. Frequently, control of translation and accelerated depletion of target mRNA is effected by antisense ODNs in eucaryotic organisms like yeast, insects or mammals. In Table 2 a series of reported natural sense/antisense interaction is listed. In case given, sequences involved in such interactions are also potential elements of therapeutic antisense action. 

Non-tempiate strand Coding strand Sense strand Tempiate strand Non-coding strand Non-sense strand... 

Non-coding strand by convention (JCBN/NC-lUB Newsletter, 1989, reproduced in Biochemical Nomenclature Related Documents - A Compendium, 2nd Edition 1992), the strand of a double-stranded stretch of DNA that has the complementary nucleotide sequence to that of the RNA transcript (e.g. mRNA) that is derived bom that double-stranded DNA. ft is therefore the DNA strand that acts as the template for the RNA transcript and could thus be called the template strand. Alternative, but in the opinion of the 1989 JCBN/NC-IUB Newsletter, less preferable names are non-sense strand and non-transcribing strand . Another alternative name is anti-sense strand . Sec Nomenclatural conventions convemed with gene transcription. 

Non-sense strand an alternative name for the Non-coding strand (see) of double-stranded DNA, which, by convention, has the complementary nucleotide sequence to that of the RNA transcript (e.g. mRNA) derived from that double-stranded DNA (save that T is in the place of U). See Nomenclatural conventions concerned with gene transcription. 

TOCSY 144 of various nuclei 141 of vicinal protons 139 Nobel prizes, list 83 Nodes of Ranvier 29 Nojirimycin tetrazole 605, 605s Non-coding (transcribing) strand in DNA 237... 

Eukaryotic rDNA is G-rich, with G-runs concentrated on the non-template strand and abundant in both coding and spacer regions. The rDNA is heavily... 

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