NO Reaction with Oi

The formation of ONOOH from ONOO yields a species with unique OH-like reactions (e.g., stimulation of membrane lipid peroxidation) via metal-independent mechanisms (Beckman et al., 1990 Radi et al., 1991a,b Ohara et al, 1994). Peroxynitrite is also capable of reaction with metal centers to yield a species with the reactivity of nitronium cation (NO2), an oxidizing and nitrating intermediate (Ischiropoulos et al., 1992). The chemistry of ONOO reactions is reviewed in more detail in the chapter by Crow and Beckman in this volume. 

Nitric oxide can act as a vitamin E-like inhibitor of radical chain propagation reactions via radical-radical reaction with cytotoxic species such as lipid peroxyi (LOO-) and aikoxyl (LO-) radicals. Nitric oxide reacts with yLO- and LOO- at near-diffusion-limited rates (for LOO-, ife = 1.3 X 10 M sec ) (Padmaja and Huie, 1993). This rate constant 

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