NO Formation by an NOS-independent Pathway

It has been found that oxime (Fig. 10.4d) and hydroxyurea (Fig. 10.4f) as well as N-hydroxyguanidine (Fig. 10.4e) also release NO via an NOS-independent pathway as described below. 

1 Ignarro, L. J., Biosynthesis and metabolism of endothelium-derived nitric oxide, Annu. Rev. Pharmacol. Toxicol. 30 (1990), p. 535-560 

Wiseman, J. N. omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine,J. Biol. Chem. 266 (1991), p. 6259-6263 

3 Ignarro, L. J., Buga, G. M., Wood, K.S., Byrns, R.E., Chaudhuri, G., Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide, Proc. Natl. Acad. Sci. USA 84 (1987), p. 9265-9269 

4 Palmer, R. M., Ferrige,A. G., Moncada, S., Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor, Nature 327 (1987), p. 524-526 

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