NMR Probe Technology Developments

Cryogenically cooled NMR probes are not a new idea. It has been known for a considerable period of time that by cooling the probe of coils and associated electronics 

Based on experience in one of the author s laboratories (GEM), cryogenic NMR probe technology may have the single biggest positive impact on increasing the facility with which long-range heteronuclear chemical shift correlation data may be acquired. 

To illustrate this point, a comparison of the results obtained with a conventional 3 mm gradient inverse triple resonance and 5 mm cryogenic gradient inverse probe technology for the acquisition of long-range data was performed. Using a 2 mg sample of the 

When these data were projected through the F frequency domain, despite the short acquisition time of 26 min, a sin ratio of 101 1 was obtained, highlighting the considerable advantage of acquiring long-range heteronuclear shift correlation 

As more laboratories gain access to cryogenic NMR probe technology, the volume of and rate at which N chemical shift data and information about long-range coupling 

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