NMR binding studies

Larive, C. K., Rogers, A., Morton, M., and Carper, W. R. (1996). 113Cd NMR binding studies of Cd-Fulvic acid complexes Evidence of fast exchange. Environ. Sci. Technol. 30, 2828-2831. 

Finally, the recognition of axially chiral l,12-dimethylbenzo[c]phenan-threne-5,8-dicarboxylate (1) enantiomers by cyclodextrins was found to be much more efficient [19]. The preliminary H NMR binding studies in D20 showed no changes in spectra of the substrate after addition of a-cyclodextrin. However, in the spectra of the (P) and (M) enantiomers of the tetrahelicene 1, significant chemical shift changes occurred after the addition of (3-cyclodextrin and y-cyclodextrin. Detailed measurements were performed to determine complexation constants and using the ROESY 2D NMR spectra the structures... 

Key Words NMR binding studies solution structure drug design binding mode screening binding site. 

---