NMDA receptor subunit mRNAs in the lumbar spinal cord

NMDA RECEPTOR SUBUNIT mRNAs IN THE LUMBAR SPINAL CORD 

I to III), NR 1-2 (C2 only) and NR 1-4 (no Cl or C2) there is little NR 1-3 (Cl only) mRNA (Luque et al., 1994 Tolle et al., 1995a,b). NRl-b (exon 5 insertion) RNA is found mainly in dorsal horn neurons in laminae II and III, but also in some neurons in layers 1 and Il-outer, and in some laminae IV and V cells (Tolle et al., 1995a) (Fig. 20). Ventral horn motor neurons have mainly NRl-a, NR 1-2 and NR I-4 RNAs. NRl-1 RNA, which gives no ventral horn signal on X-ray film autoradiography, is enriched in the nuclei of motor neurons this may reflect part of the splicing control mechanism, and that this RNA is not available for translation (Tolle et al., 1995a,b). 

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