Nitrosamines shifts 246

Compared to the worst case exposure from the fourth NIOSH survey, a worker in this area now would inhale approximately 6.0 yg of nitrosamines per shift, an exposure equivalent to eating a few strips of bacon and drinking a liter of beer. 

Table 4.47. 13C Chemical Shifts of N-Alkyl Carbons in N-Nitrosamines (<5C in ppm) [361].

With a primary amine, the initially formed A -nitrosamine can undergo a proton shift by a sequence analogous to interconversion of a ketone to an enol. The product is called a diazoic acid ... 

Chemically, the dithiocarbamate class of rubber accelerators is actually salts of the thiurams. And just as with the thiuram class, the dithiocarbamates can also emit nitrosamines during the curing process, which can pose a health risk to workers. This is why over the years there has been some shifting of use in rubber accelerators away from the dithiocarbamates. 

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