3- nitrophenyl 2- phenyl

Outline a reasonable synthesis of 4 nitrophenyl phenyl ether from chlorobenzene and phenol... 

Hydrazides are formed by the acylation of hydrazines, and have a C-N bond of rather low chemical stability toward hydrolysis. It is, therefore, not surprising that the cleavage of this bond represents a major metabolic pathway for most hydrazides. The reaction is catalyzed by amidases since it can be inhibited by O-ethyl 0-(4-nitrophenyl) phenyl phosphothionate or bis(4-nitrophenyl) phosphate, which are classical inhibitors of this enzyme. 

FIGURE 7. Br0nsted-type plot for the reaction of the oximates with the bis(4-nitrophenyl) phenyl-phosphonate at 25 °C in aqueous solution. From Terrier et al, Chem. Commun., 600 (2003). Reproduced by permission of The Royal Society of Chemistry... 

Aminolysis of a series of aryl 2,4-dinitrophenyl carbonates by a series of quinuclidines gave linear Br0nsted-type plots, the magnitudes of their slopes confirming their mechanisms as concerted.40 A comparison41 of the aminolysis, by primary amines, of 4-nitrophenyl phenyl carbonate (31 X = O) with its thiono analogue (31 X = S) is discussed in the section Thioacids, Thioesters, Thiolactones, and Thiocarbonates below. 

Diphenyl ether 2-Nitrophenyl phenyl ether 4-Nitrophenyl phenyl ether... 

E-3-[6 -Methyl-2 -(4"-nitrophenyl)phenyl]propenoic Acid Methyl Ester (21) [7]... 

Benzophenone was converted in the presence of a catalytic amount of hydrogen fluoride to a,a-difluorobenzyl phenyl ether, while exclusive phenyl ring migration was observed in reaction with 4-nitrophenyl phenyl ether107. 

Atallah, Y.H., W.P. Cahill and D.M. Whitacre (1982). Exposure of pesticide applicators and support personnel to 0-ethyl-0-(4-nitrophenyl)phenyl phosphonothionate (EPN), Arch. Environ. Contam. Toxicol., 11, 219-225. 

Also in the diphenylether series, 4-nitrophenol in dry pyridine containing Cu(l)phenylacetylide after refluxing under nitrogen for 10 hours and then treatment with bromobenzene followed by further refluxing during 4 hours, furnished 4-nitrophenyl phenyl ether in 70-77% yield (ref.64). 

Cleavage at the phosphorus-carbon bond in esters of (trichloromethyl)phosphonic acid under alkaline conditions has been known for many years and yields ethanol, phosphoric acid and chloroform, and a study of the kinetics has shown that as the concentration of alkali rises, CO, HCl and HCOOH are formed in increasing amounts, possibly through the sequence illustrated in Scheme 9. However, hydrolytic removal of the trichloromethyl group is possible in conditions other than alkaline. At pH 1-10, 4-nitrophenyl phenyl(trichloromethyl)phosphinate is cleaved at the P—C bond to the extent of90-100%, although this is accompanied by hydrolysis at the POC bonding with the liberation of small... 

PHOSPHORYLATION Di-f-butyl phos-phorobromidate. 4-Nitrophenyl phenyl phosphorochloridafe. 

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