Nitroolefins enamine catalysis

In 2007, Connon and McCooey developed highly efficient, asymmetric syn-selective addition reactions of enolizable carbonyl compounds to nitroolefins by adopting the enamine catalysis approach [48]. The 9-epi-amino cinchona alkaloid derivative (160,9 -epi-DHQDA) as an aminocatalyst promoted the addition ofa variety... 

As for iminium catalysis, the enamine Michael addition was shown to have a great potential for the fast construction of simple drugs. The group led Benjamin List reported on the highly challenging addition of acetaldehyde to nitroolefins for the synthesis of three different small bioactive natural products (Scheme 11.21). " The Michael adducts 83 obtained using commercial catalyst in 88% to 94% ee and containing both aldehyde and nitro functionality could be transformed by a classic one- to three-step transformation... 

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