Nitroglycerin dosage

As a result of salivary flow, drag concentrations in this region are sustained only for a relatively short period of time, probably in the order of minutes. For these reasons, the sublingual route is ideally suited to the delivery of low molecular weight lipophilic drags where rapid onset of action is required (e.g. nitroglycerin). Dosage forms that have been developed that are suitable for these types of applications include ... 

Discontinuation Discontinue sublingual nitroglycerin if blurring of vision or drying of the mouth occurs. Excessive dosages of nitroglycerin may produce severe headaches. 

W. G. Crouthamel and B. Dorsch, Specific high-performance liquid chromatographic assay for nitroglycerin in dosage forms, J. Pharm. Sci., 68 231 (1979). 

Early recognition of buccal and sublingual absorption was manifested in the use of nitroglycerin by these dosage routes to treat severe headache and to relieve angina pectoris. 

Iga, K. Ogawa, Y. Sustained-Release buccal dosage forms for nitroglycerin and isosorbide dinitrate increased bioavailability and extended time of absorption when administered to dogs. J. Controlled Release 1997, 49, 105-113. 

Povidone is capable of chemically stabilizing certain active ingredients. This effect does not depend on the dosage form, as povidone is used to stabilize nitroglycerin and isosorbide dinitrate, particularly in transdermal systems [384-386],... 

Yes, if large doses are given, or if dosage is constant. Thus, nitroglycerine is best suited for intermittent (acute) therapy. 

A. Classification and Pharmacokinetics Nitroglycerin (the active ingredient in dynamite) is the most important of the nitrates and is available in forms that provide a range of durations of action from 10-20 minutes (sublingual) to 8-10 hours (transdernial) (Table 12-2). Because treatment of acute attacks and prevention of attacks are both important aspects of therapy, the pharmacokinetics of these different dosage forms are clinically significant. 

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