Nitrogen rings synthesis

There are only few reactions known introducing substituents to the H-bearing nitrogen of oxaziridines. (V-Alkylation of l-oxa-2-azaspiro[2.5]octane (3,3-pentamethylene-oxaziridine 52) with r-butyl chloride to give (53) was carried out for structure proof of (52). This reaction is of no preparative importance, since N-alkylated oxaziridines are easily obtained by ring synthesis. 

A BCA similar to DOTA is l,4,7-triazacyclononane-N,N, N"-triacetic acid (NOTA). NOTA contains a smaller ring structure in comparison to DOTA and only has three chelating nitrogen groups. Synthesis of functional derivatives can be done... 

Nucleophilic displacement of chloro groups by fluoride was accomplished under pyrolysis conditions with potassium fluoride the chloro (and bromo) precursors are available by ring-synthesis [78HC(33)1 79CB1529 84MI7]. Halogens next to annular nitrogens are the most easily displaced,... 

Nitriles and nitrilium salts, heterocyclic synthesis involving, 6, 95 Nitro-compounds, heteroaromatic, ring synthesis of, 25, 113 Nitrogen-bridged six-membered ring systems, 16, 87... 

Hartough, Thiophene and Its Derivatives, Interscience Publishers, New York, 1951 Hollins, The Synthesis of Nitrogen Ring Compounds, E. Benn, Ltd., London, 1924. 

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