Nitrofen, teratogen

Daston GP, Rehnherg BP, Carver B, et ah Punctional teratogens of the rat kidney. II. Nitrofen and ethylenethiourea. Fundam Appl Toxicol 11(3) 401 15, 1988... 

A foreign compound, which may act in this way is the herbicide nitrofen (2,4-dichloro-4 -nitro diphenyl ether), which causes a variety of malformations lethal to the neonate. There is no growth retardation or embryolethality at doses, which are teratogenic, however (Fig. 6.27), and therefore this exhibits the first type of dose-response relationship (see above). The... 

FIGURE 6.18 The dose-response patterns for teratogenicity caused by the herbicide nitrofen (2,4-dichloro-4 -nitro diphenyl ether). Pregnant rats were treated on day 11 with nitrofen. Data from Manson, J.M., Teratogens, in Casarett and Doull s Toxicology, edited by C.D.Klaassen, M.O.Amdur andJ. Doull (New York Macmillan), 3rd Edition, 1986. 

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