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Nitriles, acid catalyzed addition ammonia

The Strecker reaction [1] starting from an aldehyde, ammonia, and a cyanide source is an efficient method for the preparation of a-amino acids. A popular version for asymmetric purposes is based on the use of preformed imines 1 and a subsequent nucleophilic addition of HCN or TMSCN in the presence of a chiral catalyst [2], Besides asymmetric cyanations catalyzed by metal-complexes [3], several methods based on the use of organocatalysts have been developed [4-14]. The general organocatalytic asymmetric hydrocyanation reaction for the synthesis of a-amino nitriles 2 is shown in Scheme 5.1. [Pg.85]

Pd-catalyzed hydrogenation of nitriles generally requires the use of acidic conditions or the addition of ammonia to minimize the formation of dialkyl and trialkyl amines (Scheme... [Pg.1077]


See other pages where Nitriles, acid catalyzed addition ammonia is mentioned: [Pg.724]    [Pg.489]    [Pg.456]    [Pg.489]    [Pg.456]    [Pg.149]    [Pg.170]    [Pg.22]    [Pg.408]    [Pg.211]    [Pg.650]    [Pg.130]    [Pg.409]   
See also in sourсe #XX -- [ Pg.1296 ]




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